Handcuffs for bacteria - NDP52 orchestrates xenophagy of intracellular Salmonella

نویسندگان

  • Pauline Verlhac
  • Christophe Viret
  • Mathias Faure
چکیده

Pauline Verlhac 1,2,3,4,5 , Christophe Viret 1,2,3,4,5 and Mathias Faure 1,2,3,4,5, * 1 CIRI, International Center for Infectiology Research, Université de Lyon, 69007 Lyon, France. 2 Inserm, U1111, 69007 Lyon, France. 3 CNRS, UMR5308, 69007 Lyon, France. 4 Ecole Normale Supérieure de Lyon, 69007 Lyon, France. 5 Université Lyon 1, Centre International de Recherche en Infectiologie, 69007 Lyon, France. * Corresponding Author: Mathias Faure, CIRI, INSERM U1111, CNRS UMR 5308, ENL-L, UCBL1 21, Avenue Tony Garnier; 69365 Lyon Cedex 07, France; Tel: +33 4 37 28 23 42; Fax: +33 4 37 28 23 41; E-mail: [email protected]

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The ubiquitin-like modifier FAT10 decorates autophagy-targeted Salmonella and contributes to Salmonella resistance in mice.

Bacterial invasion of eukaryotic cells is counteracted by cell-autonomous innate immune mechanisms including xenophagy. The decoration of cytosolic bacteria by ubiquitylation and binding of galectin-8 leads to recruitment of autophagy adaptors like p62 (also known as SQSTM1), NDP52 (also known as CALCOCO2) and optineurin, which initiate the destruction of bacteria by xenophagy. Here, we show th...

متن کامل

The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy

Autophagy plays a key role during Salmonella infection, by eliminating these pathogens following escape into the cytosol. In this process, selective autophagy receptors, including the myosin VI adaptor proteins optineurin and NDP52, have been shown to recognize cytosolic pathogens. Here, we demonstrate that myosin VI and TAX1BP1 are recruited to ubiquitylated Salmonella and play a key role in x...

متن کامل

Expanding the host cell ubiquitylation machinery targeting cytosolic Salmonella.

Ubiquitylation is one of the cardinal post-translational modifications in the cell, balancing several distinct biological processes and acting as a pathogen recognition receptor during bacterial pathogen invasion. A dense layer of polyubiquitin chains marks invading bacteria that gain access to the host cytosol for their selective clearance via xenophagy. However, the enzymes that mediate recog...

متن کامل

Essential role for the mammalian ATG8 isoform LC3C in xenophagy.

In this issue, Randow and coworkers (von Muhlinen et al., 2012) report that LC3C plays an essential role in Salmonella clearance by interacting with the autophagic receptor NDP52, with consequent recruitment of all other ATG8 proteins to assist in the buildup of the autophagic membrane.

متن کامل

A Structural View of Xenophagy, a Battle between Host and Microbes

The cytoplasm in mammalian cells is a battlefield between the host and invading microbes. Both the living organisms have evolved unique strategies for their survival. The host utilizes a specialized autophagy system, xenophagy, for the clearance of invading pathogens, whereas bacteria secrete proteins to defend and escape from the host xenophagy. Several molecules have been identified and their...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2015